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Highly Responsive and Ultrasensitive Non-Enzymatic Electrochemical Glucose Sensor Based on Au Foam

2019-04-11

Authors: Shen, NN; Xu, HJ; Zhao, WC; Zhao, YM; Zhang, X
SENSORS
Volume: 19 Issue: 5 Published: MAR 1 2019 Language: English Document type: Article
DOI: 10.3390/s19051203
Abstract:
Glucose concentration is an important physiological index, therefore methods for sensitive detection of glucose are important. In this study, Au foam was prepared by electrodeposition with a dynamic gas template on an Au nanoparticle/Si substrate. The Au foam showed ultrasensitivity, high selectivity, and long-term stability in the quantitative detection of glucose. The foam was used as an electrode, and the amperometric response indicated excellent catalytic activity in glucose oxidation, with a linear response across the concentration range 0.5 mu M to 12 mM, and a limit of detection of 0.14 mu M. High selectivity for interfering molecules at six times the normal level and long-term stability for 30 days were obtained. The results for electrochemical detection with Au foam of glucose in human serum were consistent with those obtained with a sensor based on surface-enhanced Raman spectroscopy and a commercial sensor. This proves that this method can be used with real samples. These results show that Au foam has great potential for use as a non-enzymatic glucose sensor.
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